Proteomic analysis reveals differentially expressed proteins in the rat frontal cortex after methamphetamine treatment

@article{Faure2009ProteomicAR,
  title={Proteomic analysis reveals differentially expressed proteins in the rat frontal cortex after methamphetamine treatment},
  author={Jean-Marc Faure and Suz{\'e}l M. Hattingh and D. J. Stein and W. M. Daniels},
  journal={Metabolic Brain Disease},
  year={2009},
  volume={24},
  pages={685-700}
}
Methamphetamine (MA) is an addictive psycho-stimulant and the illicit use of the drug is escalating. In the present study, we examined protein expression profiles in the rat frontal cortex exposed to a total of eight MA injections (1 mg/kg, intraperitoneal) using 2-DE based proteomics. We investigated protein changes occurring in both the cytosolic fraction and the membrane fraction. 2-DE analysis resulted in 62 cytosolic and 44 membrane protein spots that were differentially regulated in the… CONTINUE READING

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