Proteomic analysis reveals cellular pathways regulating carbohydrate metabolism that are modulated in primary human skeletal muscle culture due to treatment with bioactives from Artemisia dracunculus L.

@article{Scherp2012ProteomicAR,
  title={Proteomic analysis reveals cellular pathways regulating carbohydrate metabolism that are modulated in primary human skeletal muscle culture due to treatment with bioactives from Artemisia dracunculus L.},
  author={Peter Scherp and Nagireddy Putluri and Gary J LeBlanc and Zhong Wang and Xian Hong Zhang and Yongmei Yu and David Ribnicky and William T. Cefalu and Indu Kheterpal},
  journal={Journal of proteomics},
  year={2012},
  volume={75 11},
  pages={3199-210}
}
Insulin resistance is a major pathophysiologic abnormality that characterizes metabolic syndrome and type 2 diabetes. A well characterized ethanolic extract of Artemisia dracunculus L., termed PMI 5011, has been shown to improve insulin action in vitro and in vivo, but the cellular mechanisms remain elusive. Using differential proteomics, we have studied mechanisms by which PMI 5011 enhances insulin action in primary human skeletal muscle culture obtained by biopsy from obese, insulin-resistant… CONTINUE READING

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