Proteomic analysis reveals a novel role for the actin cytoskeleton in vincristine resistant childhood leukemia--an in vivo study.

@article{Verrills2006ProteomicAR,
  title={Proteomic analysis reveals a novel role for the actin cytoskeleton in vincristine resistant childhood leukemia--an in vivo study.},
  author={Nicole M. Verrills and Natalia L. M. Liem and Tracy Y.E. Liaw and Brian D Hood and Richard B. Lock and Maria Kavallaris},
  journal={Proteomics},
  year={2006},
  volume={6 5},
  pages={
          1681-94
        }
}
Intrinsic or acquired resistance to vincristine (VCR), an antimicrotubule agent used in the treatment of childhood acute lymphoblastic leukemia (ALL), is a major clinical problem. Using a clinically relevant NOD/SCID mouse xenograft model of ALL, we established that alterations in the actin and tubulin cytoskeleton are involved in in vivo VCR resistance. Altered protein expression between VCR-sensitive ALL xenografts, and xenografts with intrinsic or acquired VCR resistance, was identified… CONTINUE READING
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