Proteomic analysis reveals a novel mechanism induced by the leukemic oncogene Tel/PDGFRβ in stem cells: activation of the interferon response pathways.

@article{Dobbin2010ProteomicAR,
  title={Proteomic analysis reveals a novel mechanism induced by the leukemic oncogene Tel/PDGFRβ in stem cells: activation of the interferon response pathways.},
  author={Edwina Dobbin and Christopher J. Graham and Robin W Freeburn and Richard D. Unwin and John R. Griffiths and Andrew Pierce and Anthony D. Whetton and Helen Wheadon},
  journal={Stem cell research},
  year={2010},
  volume={5 3},
  pages={226-43}
}
Objective proteomic analysis offers opportunities for hypothesis generation on molecular events associated with pathogenesis in stem cells. Relative quantification mass spectrometry was employed to identify pathways affected by Tel/PDGFRβ, an oncogene associated with myeloproliferative neoplasia (MPN). Its effects on over 1800 proteins were quantified with high confidence. Of those up-regulated by Tel/PDGFRβ several were involved in the interferon gamma (IFNγ) response. To validate these… CONTINUE READING