Proteomic analysis of zebrafish (Danio rerio) embryos exposed to cyclosporine A.

@article{Ponnudurai2012ProteomicAO,
  title={Proteomic analysis of zebrafish (Danio rerio) embryos exposed to cyclosporine A.},
  author={Ruby P Ponnudurai and T. K. Basak and Shadab Ahmad and Gourav Bhardwaj and Rajendra Kumar Chauhan and Ramcharan A Singh and Mukesh Kumar Lalwani and Sridhar Sivasubbu and Shantanu Sengupta},
  journal={Journal of proteomics},
  year={2012},
  volume={75 3},
  pages={1004-17}
}
Cyclosporine A, a potent immunosuppressive agent extensively used to prevent allograft rejections, is under scrutiny due to severe toxic effects. CsA therapy is often continued during pregnancy in conditions such as organ transplantations and autoimmune diseases. Herein, we investigated the effects of CsA on early morphogenesis of zebrafish and identified a spectrum of proteins whose expression was altered in the drug treated embryos. Time-lapse fluorescence imaging of germ-line double… CONTINUE READING
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