Proteomic analysis of the tumorigenic human prostate cell line M12 after microcell-mediated transfer of chromosome 19 demonstrates reduction of vimentin.

@article{Liu2003ProteomicAO,
  title={Proteomic analysis of the tumorigenic human prostate cell line M12 after microcell-mediated transfer of chromosome 19 demonstrates reduction of vimentin.},
  author={Xuhui Liu and Yongzhong Wu and Zendra E. Zehner and Colleen K Jackson-Cook and Joy L. Ware},
  journal={Electrophoresis},
  year={2003},
  volume={24 19-20},
  pages={
          3445-53
        }
}
Critical alterations in proteins that accompany or control the aggressiveness of human prostate cancers remain poorly defined. Previously we demonstrated that the highly tumorigenic, metastatic human prostate cell line M12 was converted to a slow growing, poorly tumorigenic cell line by introduction of an intact human chromosome 19, generating the M12 (F6) hybrid cells. The objective of this report was to identify changes in the protein profile of these M12(F6) microcell hybrid cells. A… CONTINUE READING

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