Proteomic analysis of the human colon carcinoma cell line (LIM 1215): development of a membrane protein database.

Abstract

The proteomic definition of plasma membrane proteins is an important initial step in searching for novel tumor marker proteins expressed during the different stages of cancer progression. However, due to the charge heterogeneity and poor solubility of membrane-associated proteins this subsection of the cell's proteome is often refractory to two-dimensional… (More)

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