Proteomic analysis of the human brain in Huntington's Disease indicates pathogenesis by molecular processes linked to other neurodegenerative diseases and to type-2 diabetes.

@article{Schnberger2013ProteomicAO,
  title={Proteomic analysis of the human brain in Huntington's Disease indicates pathogenesis by molecular processes linked to other neurodegenerative diseases and to type-2 diabetes.},
  author={Sarah J Sch{\"o}nberger and Dina Jezdic and Richard L. M. Faull and Garth J S Cooper},
  journal={Journal of Huntington's disease},
  year={2013},
  volume={2 1},
  pages={89-99}
}
BACKGROUND Huntington's disease (HD) is a neurodegenerative disorder in which the aetiological defect is inherited or spontaneous mutation in the HTT gene, which alters the structure of the corresponding huntingtin protein and initiates a pathogenetic cascade that ultimately leads to or causes dementia. OBJECTIVE Here our main objective was to elucidate further the pathogenic processes that underlie neurodegeneration in HD. METHODS By using two-dimensional gel electrophoresis we performed a… CONTINUE READING

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