Proteomic analysis of the E2F1 response in p53-negative cancer cells: new aspects in the regulation of cell survival and death.

@article{Li2006ProteomicAO,
  title={Proteomic analysis of the E2F1 response in p53-negative cancer cells: new aspects in the regulation of cell survival and death.},
  author={Zhenpeng Li and Michael Kreutzer and Stefan Mikkat and Nikica Mise and Michael O. Glocker and Brigitte M. P{\"u}tzer},
  journal={Proteomics},
  year={2006},
  volume={6 21},
  pages={5735-45}
}
E2F1 is an essential transcription factor that regulates cell-cycle progression and apoptosis. Overexpression of E2F1 sensitizes neoplastic cells to apoptosis and leads to tumor growth suppression, making it an interesting target for anticancer therapy. Use of E2F1 as a therapeutic, however, requires a detailed knowledge of the mechanisms by which it controls cellular proliferation and apoptosis, and of other potential E2F1 activities. In this study, a differential proteome analysis was… CONTINUE READING
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