Proteomic analysis of the CSF in unmedicated patients with major depressive disorder reveals alterations in suicide attempters

@article{Brunner2005ProteomicAO,
  title={Proteomic analysis of the CSF in unmedicated patients with major depressive disorder reveals alterations in suicide attempters},
  author={Dr. med. Mag. Dipl. oec. med. J{\"u}rgen Brunner and Th. Bronisch and M. Uhr and Marcus Ising and Elisabeth E. Binder and Florian Holsboer and Christoph Wilhelm Turck},
  journal={European Archives of Psychiatry and Clinical Neuroscience},
  year={2005},
  volume={255},
  pages={438-440}
}
This is the first report on proteomic analysis of the cerebrospinal fluid (CSF) in unmedicated suicide attempters and non-attempters with major depressive disorder.Two-dimensional (2D) gel electrophoresis revealed that suicide attempters differed from non-attempters in one protein with an approximate molecular weight of 33 kD and an isoelectric point of 5.2. Proteomic analysis of the CSF is a promising non hypothesis-driven screening method for the detection of new candidate genes in… CONTINUE READING