Proteomic analysis of selenium embryotoxicity in cultured postimplantation rat embryos.

@article{Usami2008ProteomicAO,
  title={Proteomic analysis of selenium embryotoxicity in cultured postimplantation rat embryos.},
  author={Makoto Usami and Katsuyoshi Mitsunaga and Kazuharu Nakazawa and Osamu Doi},
  journal={Birth defects research. Part B, Developmental and reproductive toxicology},
  year={2008},
  volume={83 2},
  pages={
          80-96
        }
}
BACKGROUND Developmental toxicity of selenium (Se) is a nutritional, environmental and medicinal concern. Here, we investigated Se embryotoxicity by proteomic analysis of cultured rat embryos. METHODS Rat embryos at day 9.5 or 10.5 of gestation were cultured for 48 or 24 h, respectively, in the presence of sodium selenate (100 or 150 microM) or sodium selenite (20 or 30 microM). Proteins from the embryo proper and yolk sac membrane were analyzed by two-dimensional electrophoresis for… CONTINUE READING
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