Proteomic analysis of secreted proteins in early rheumatoid arthritis: anti-citrulline autoreactivity is associated with up regulation of proinflammatory cytokines.

@article{Hueber2007ProteomicAO,
  title={Proteomic analysis of secreted proteins in early rheumatoid arthritis: anti-citrulline autoreactivity is associated with up regulation of proinflammatory cytokines.},
  author={Wolfgang Hueber and Beren H. Tomooka and Xiaoyan Zhao and Brian A. Kidd and Jan Wouter Drijfhout and James F. Fries and Walther J. van Venrooij and Allan L. Metzger and Mark C Genovese and William H Robinson},
  journal={Annals of the rheumatic diseases},
  year={2007},
  volume={66 6},
  pages={712-9}
}
OBJECTIVES To identify peripheral blood autoantibody and cytokine profiles that characterise clinically relevant subgroups of patients with early rheumatoid arthritis using arthritis antigen microarrays and a multiplex cytokine assay. METHODS Serum samples from 56 patients with a diagnosis of rheumatoid arthritis of <6 months' duration were tested. Cytokine profiles were also determined in samples from patients with psoriatic arthritis (PsA) and ankylosing spondylitis (n = 21), and from… CONTINUE READING

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