Proteomic analysis of primary cell lines identifies protein changes present in renal cell carcinoma.

@article{Craven2006ProteomicAO,
  title={Proteomic analysis of primary cell lines identifies protein changes present in renal cell carcinoma.},
  author={Rachel A. Craven and Anthea J. Stanley and Sarah Ann Hanrahan and James S Dods and Richard D. Unwin and Nicholas F. Totty and Patricia M Harnden and Ian Eardley and Peter John Selby and Rosamonde E. Banks},
  journal={Proteomics},
  year={2006},
  volume={6 9},
  pages={
          2853-64
        }
}
New markers/targets for renal cell carcinoma (RCC) are needed to enable earlier detection and monitoring of disease and therapeutic targeting. To identify such molecules, normal and RCC-derived primary cell lines have been used as a simplified model system for studying changes that accompany tumorigenesis. Short-term cultures allow enrichment of relevant cell types from tissue samples, which is balanced against the potential for in vitro changes. Examination of 3 proteins with altered… CONTINUE READING
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