Proteomic analysis of post-translational modifications

@article{Mann2003ProteomicAO,
  title={Proteomic analysis of post-translational modifications},
  author={Matthias Mann and Ole N{\o}rregaard Jensen},
  journal={Nature Biotechnology},
  year={2003},
  volume={21},
  pages={255-261}
}
Post-translational modifications modulate the activity of most eukaryote proteins. Analysis of these modifications presents formidable challenges but their determination generates indispensable insight into biological function. Strategies developed to characterize individual proteins are now systematically applied to protein populations. The combination of function- or structure-based purification of modified 'subproteomes', such as phosphorylated proteins or modified membrane proteins, with… Expand
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