Proteomic analysis of polymorphonuclear neutrophils identifies catalase as a novel biomarker of abdominal aortic aneurysm: potential implication of oxidative stress in abdominal aortic aneurysm progression.

@article{RamosMozo2011ProteomicAO,
  title={Proteomic analysis of polymorphonuclear neutrophils identifies catalase as a novel biomarker of abdominal aortic aneurysm: potential implication of oxidative stress in abdominal aortic aneurysm progression.},
  author={Priscila Ramos-Mozo and Julio Madrigal-Matute and Roxana Mart{\'i}nez-Pinna and Lu{\'i}s Miguel Blanco-Colio and Juan A L{\'o}pez and Emilio Camafeita and Olivier Meilhac and Jean-Baptiste Michel and C{\'e}sar Aparicio and Melina Vega de C{\'e}niga and Jes{\'u}s Egido and Jos{\'e}-Luis Martin-Ventura},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2011},
  volume={31 12},
  pages={3011-9}
}
OBJECTIVE Polymorphonuclear neutrophils (PMNs) play a main role in abdominal aortic aneurysm (AAA) progression. We have analyzed circulating PMNs isolated from AAA patients and controls by a proteomic approach to identify proteins potentially involved in AAA pathogenesis. METHODS AND RESULTS PMNs from 8 AAA patients (4 large AAA >5 cm and 4 small AAA 3-5 cm) and 4 controls were analyzed by 2D differential in-gel electrophoresis. Among differentially expressed spots, several proteins involved… CONTINUE READING