Proteomic analysis of osteoarthritic chondrocyte reveals the hyaluronic acid-regulated proteins involved in chondroprotective effect under oxidative stress.

@article{Yu2014ProteomicAO,
  title={Proteomic analysis of osteoarthritic chondrocyte reveals the hyaluronic acid-regulated proteins involved in chondroprotective effect under oxidative stress.},
  author={Chia-Jung Yu and Chun-Jung Ko and Chang-Hsun Hsieh and Chiang-Ting Chien and Lien-Hung Huang and Chien-Wei Lee and C. I. Jiang},
  journal={Journal of proteomics},
  year={2014},
  volume={99},
  pages={
          40-53
        }
}
UNLABELLED Osteoarthritis (OA), the most common type of arthritis, is a degenerative joint disease. Oxidative stress is well known to play important roles in cartilage degradation and pathogenesis of OA. The intra-articular injection of hyaluronic acid (IAHA) is accepted as an effective clinical therapy for OA, but we do not yet fully understand the mechanisms underlying the effects of HA on OA chondrocytes under oxidative stress. Here, we show for the first time that IAHA significantly reduces… CONTINUE READING
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