Proteomic analysis of malignant lymphocyte membrane microparticles using double ionization coverage optimization.

@article{Miguet2006ProteomicAO,
  title={Proteomic analysis of malignant lymphocyte membrane microparticles using double ionization coverage optimization.},
  author={Laurent Miguet and Karine Pacaud and Claire Felden and B{\'e}n{\'e}dicte Hugel and Mar{\'i}a del Carmen Mart{\'i}nez and J. -M. Freyssinet and Raoul Herbrecht and Noelle Potier and Alain van Dorsselaer and Laurent Mauvieux},
  journal={Proteomics},
  year={2006},
  volume={6 1},
  pages={153-71}
}
Shed membrane microparticles (MPs) are microvesicles generated from the plasma membrane when cells are submitted to stress conditions. Although MPs reflect the cell state (at least in vitro), little is known on their protein composition. We describe the first set of experiments aiming to characterize the MP proteome. Two ways of triggering MP formation from a T-lymphocytic cell line were analyzed using a 1-D gel approach coupled with LC-MS/MS and the results were compared with those obtained… CONTINUE READING

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