Proteomic analysis of host responses in HepG2 cells during dengue virus infection.

@article{Pattanakitsakul2007ProteomicAO,
  title={Proteomic analysis of host responses in HepG2 cells during dengue virus infection.},
  author={Sa-nga Pattanakitsakul and Kamonthip Rungrojcharoenkit and Rattiyaporn Kanlaya and Supachok Sinchaikul and Sansanee Noisakran and Shui-Tein Chen and Prida Malasit and Visith Thongboonkerd},
  journal={Journal of proteome research},
  year={2007},
  volume={6 12},
  pages={
          4592-600
        }
}
Dengue virus infection remains a public health problem worldwide. However, its pathogenic mechanisms and pathophysiology are still poorly understood. We performed proteomic analysis to evaluate early host responses (as indicated by altered proteins) in human target cells during dengue virus infection. HepG2 cells were infected with dengue virus serotype 2 (DEN-2) at multiplicity of infection (MOI) of 0.1, 0.5, and 1.0. Quantitative analyses of DEN-2 infection and cell death at 12, 24, and 48 h… Expand
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