Proteomic analysis of fructose-induced fatty liver in hamsters.

  title={Proteomic analysis of fructose-induced fatty liver in hamsters.},
  author={Lihe Zhang and Germ{\'a}n Perdomo and Dae Hyun Kim and Shen Qu and Steven Ringquist and Massimo Trucco and Henry H. Dong},
  journal={Metabolism: clinical and experimental},
  volume={57 8},
High fructose consumption is associated with the development of fatty liver and dyslipidemia with poorly understood mechanisms. We used a matrix-assisted laser desorption/ionization-based proteomics approach to define the molecular events that link high fructose consumption to fatty liver in hamsters. Hamsters fed high-fructose diet for 8 weeks, as opposed to regular-chow-fed controls, developed hyperinsulinemia and hyperlipidemia. High-fructose-fed hamsters exhibited fat accumulation in liver… CONTINUE READING


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