Proteomic analysis of fatty-acylated proteins.

  title={Proteomic analysis of fatty-acylated proteins.},
  author={T. A. Peng and Emmanuelle Thinon and Howard C Hang},
  journal={Current opinion in chemical biology},
Protein fatty-acylation in eukaryotes has been associated with many fundamental biological processes. However, the diversity, abundance and regulatory mechanisms of protein fatty-acylation in vivo remain to be explored. Herein, we review the proteomic analysis of fatty-acylated proteins, with a focus on N-myristoylation and S-palmitoylation. We then highlight major challenges and emerging methods for direct site identification, quantitation, and lipid structure characterization to understand… CONTINUE READING
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