Proteomic analysis of clinical isolate of Stenotrophomonas maltophilia with blaNDM-1, blaL1 and blaL2 β-lactamase genes under imipenem treatment.

@article{Liu2012ProteomicAO,
  title={Proteomic analysis of clinical isolate of Stenotrophomonas maltophilia with blaNDM-1, blaL1 and blaL2 β-lactamase genes under imipenem treatment.},
  author={Wei Liu and Dayang Zou and Xuesong Wang and Xuelian Li and Li Zhu and Zhitao Yin and Zhan Yang and Xiao Chen Wei and Li Han and Yufei Wang and Changlin Shao and Simiao Wang and Xiang He and Dawei Liu and Feng Liu and Jie Wang and Liu-yu Huang and Jing 5 Yuan},
  journal={Journal of proteome research},
  year={2012},
  volume={11 8},
  pages={4024-33}
}
The co-occurrence of L1 and AmpR-L2 with bla(NDM-1) gene with an upstream 250-bp promoter was detected in a clinical isolate of Stenotrophomonas maltophilia DCPS-01, which was resistant to all β-lactams and sensitive only to colistin and fluoroquinolones. To investigate expression of resistance genes and the molecular mechanisms of bacteria resistance to carbapenems, proteomic profiles of the isolate was passaged with and without the drug by using 2D-PAGE. The results showed that 33 genes… CONTINUE READING

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