Proteomic analysis of cerebrospinal fluid changes related to postmortem interval.

@article{Finehout2006ProteomicAO,
  title={Proteomic analysis of cerebrospinal fluid changes related to postmortem interval.},
  author={Erin J. Finehout and Zsofia Franck and Norman Relkin and Kelvin H. Lee},
  journal={Clinical chemistry},
  year={2006},
  volume={52 10},
  pages={
          1906-13
        }
}
BACKGROUND The study of proteins with altered production in postmortem cerebrospinal fluid (CSF) compared with antemortem CSF may improve the understanding of biochemical changes that occur immediately after death. METHODS Two CSF samples (1 antemortem and 1 postmortem) were collected from 7 patients and analyzed by 2-dimensional gel electrophoresis. An analysis was also performed to identify proteins that showed a correlation between concentration change and postmortem interval. Tandem mass… 
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The current status of characterization of the human CSF proteome and biomarker discovery for major neurodegenerative disorders, i.e., Alzheimer's disease and Parkinson's disease, is summarized and a few essential caveats involved in several steps of CSf proteomics are addressed.
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