Proteomic analysis of cell lines to identify the irinotecan resistance proteins

@article{Peng2010ProteomicAO,
  title={Proteomic analysis of cell lines to identify the irinotecan resistance proteins},
  author={Xing-Chen Peng and Feng-ming Gong and Meng Wei and X. Chen and Ye Chen and Ke Cheng and F. Gao and Feng Xu and Feng Bi and Jiyan Liu},
  journal={Journal of Biosciences},
  year={2010},
  volume={35},
  pages={557-564}
}
Chemotherapeutic drug resistance is a frequent cause of treatment failure in colon cancer patients. Several mechanisms have been implicated in drug resistance. However, they are not sufficient to exhaustively account for this resistance emergence. In this study, two-dimensional gel electrophoresis (2-DE) and the PDQuest software analysis were applied to compare the differential expression of irinotecan-resistance-associated protein in human colon adenocarcinoma LoVo cells and irinotecan… 

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