Proteomic analysis of breast cancer molecular subtypes and biomarkers of response to targeted kinase inhibitors using reverse-phase protein microarrays.

@article{Boyd2008ProteomicAO,
  title={Proteomic analysis of breast cancer molecular subtypes and biomarkers of response to targeted kinase inhibitors using reverse-phase protein microarrays.},
  author={Zachary S Boyd and Qun Jenny Wu and Carol O'Brien and Jill M. Spoerke and Heidi M Savage and Paul J. Fielder and Lukas C. Amler and Yibing Yan and Mark R. Lackner},
  journal={Molecular cancer therapeutics},
  year={2008},
  volume={7 12},
  pages={3695-706}
}
Although breast cancer molecular subtypes have been extensively defined by means of gene expression profiling over the past decade, little is known, at the proteomic level, as to how signaling pathways are differentially activated and serve to control proliferation in different breast cancer subtypes. We used reverse-phase protein arrays to examine phosphorylation status of 100 proteins in a panel of 30 breast cancer cell lines and showed distinct pathway activation differences between… CONTINUE READING