Proteomic analysis of brain tissue from an Alzheimer's disease mouse model by two-dimensional difference gel electrophoresis.

@article{Sizova2007ProteomicAO,
  title={Proteomic analysis of brain tissue from an Alzheimer's disease mouse model by two-dimensional difference gel electrophoresis.},
  author={Daria Sizova and Elodie Charbaut and François Delalande and Florence Poirier and Anthony A. High and Fabienne Parker and Alain van Dorsselaer and Marc A Duchesne and Anita Diu-Hercend},
  journal={Neurobiology of aging},
  year={2007},
  volume={28 3},
  pages={357-70}
}
We used a beta-amyloid precursor protein (APP) transgenic (Tg) mouse model that displays some of the typical Alzheimer-associated pathological features to study the brain proteoma associated with amyloid plaque deposition. Two groups (male and female) of 14-month-old Tg mice were compared with their wild type littermates. We used differential 2D electrophoresis coupled with mass spectrometry to generate one of the first complete image of changes in brain protein expression occurring in this… CONTINUE READING