Proteomic analysis of brain proteins in the gracile axonal dystrophy (gad) mouse, a syndrome that emanates from dysfunctional ubiquitin carboxyl-terminal hydrolase L-1, reveals oxidation of key proteins.

@article{Castegna2004ProteomicAO,
  title={Proteomic analysis of brain proteins in the gracile axonal dystrophy (gad) mouse, a syndrome that emanates from dysfunctional ubiquitin carboxyl-terminal hydrolase L-1, reveals oxidation of key proteins.},
  author={Alessandra Castegna and Visith Thongboonkerd and Jon B. Klein and Bert C. Lynn and Yu-lai Wang and Hitoshi Osaka and Keiji Wada and David Butterfield},
  journal={Journal of neurochemistry},
  year={2004},
  volume={88 6},
  pages={1540-6}
}
Ubiquitin carboxyl-terminal hydrolase L-1 (UCH L-1) is a crucial enzyme for proteasomal protein degradation that generates free monomeric ubiquitin. Our previous proteomic study identified UCH L-1 as one specific target of protein oxidation in Alzheimer's disease (AD) brain, establishing a link between the effect of oxidative stress on protein and the proteasomal dysfunction in AD. However, it is unclear how protein oxidation affects function, owing to the different responses of proteins to… CONTINUE READING
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