Proteomic analysis of autocrine/paracrine effects of human growth hormone in human mammary carcinoma cells.

@article{Vouyovitch2008ProteomicAO,
  title={Proteomic analysis of autocrine/paracrine effects of human growth hormone in human mammary carcinoma cells.},
  author={Cecile M. Vouyovitch and Laurent Vidal and Sahra Borg{\'e}s and Mireille Raccurt and C{\'e}cile Arnould and Jean Chiesa and Peter E. Lobie and Jo{\"e}l Lachuer and Hichem-Claude Mertani},
  journal={Advances in experimental medicine and biology},
  year={2008},
  volume={617},
  pages={493-500}
}
Human growth hormone (hGH) is expressed by mammary epithelial cells and associated with proliferative disorders of the human breast. Our goal is to characterize the paracrine effects of hGH on morphological and functional changes of mammary carcinoma cells using MCF7 cells stably transfected with the hGH gene (MCFhGH). To identify the molecular actors involved in autocrine hGH-induced cell proliferation, we have used a protein chip technology using a commercial antibody microarray. The results… CONTINUE READING

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