Proteomic analysis of autoantibodies in patients with hepatocellular carcinoma.

@article{Takashima2006ProteomicAO,
  title={Proteomic analysis of autoantibodies in patients with hepatocellular carcinoma.},
  author={Motonari Takashima and Yasuhiro Kuramitsu and Yuichiro Yokoyama and Norio Iizuka and Toshio Harada and Masanori Fujimoto and Isao Sakaida and Kiwamu Okita and Masaaki Oka and Kazuyuki Nakamura},
  journal={Proteomics},
  year={2006},
  volume={6 13},
  pages={3894-900}
}
To detect autoantibodies that could be diagnostic markers for hepatocellular carcinoma (HCC), we analyzed serum autoantibodies comprehensively that showed immunoreactivity to proteins in tumor tissue obtained from patients with HCC. Fifteen paired samples of HCC tissue and corresponding nontumorous liver tissue as well as five normal liver tissue samples were used in the study. A combination of proteomics and SEREX (serologic analysis of recombinant cDNA expression libraries) technique was used… CONTINUE READING

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