Proteomic analysis of age-dependent changes in protein solubility identifies genes that modulate lifespan

@inproceedings{ReisRodrigues2012ProteomicAO,
  title={Proteomic analysis of age-dependent changes in protein solubility identifies genes that modulate lifespan},
  author={Pedro Reis-Rodrigues and Gregg Czerwieniec and Theodore W. Peters and Uday S. Evani and Silvestre Alavez and Emily Anne Gaman and Maithili C. Vantipalli and Sean D. Mooney and Bradford W. Gibson and Gordon J. Lithgow and Robert E. Hughes},
  booktitle={Aging cell},
  year={2012}
}
While it is generally recognized that misfolding of specific proteins can cause late-onset disease, the contribution of protein aggregation to the normal aging process is less well understood. To address this issue, a mass spectrometry-based proteomic analysis was performed to identify proteins that adopt sodium dodecyl sulfate (SDS)-insoluble conformations during aging in Caenorhabditis elegans. SDS-insoluble proteins extracted from young and aged C. elegans were chemically labeled by isobaric… CONTINUE READING
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References

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SHOWING 1-10 OF 32 REFERENCES

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2009
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Multiple-stress analysis for isolation of Drosophila longevity genes.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2004
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Overexpression of the small mitochondrial Hsp22 extends Drosophila life span and increases resistance to oxidative stress.

  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2004
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Aging, protein solubility and lifespan

C. elegans, P. Reis-Rodrigues
  • 2011

Protein homeostasis and aging: taking care of proteins from the cradle to the grave.

  • The journals of gerontology. Series A, Biological sciences and medical sciences
  • 2009
VIEW 1 EXCERPT

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