Proteomic analysis of a pleistocene mammoth femur reveals more than one hundred ancient bone proteins.

@article{Cappellini2012ProteomicAO,
  title={Proteomic analysis of a pleistocene mammoth femur reveals more than one hundred ancient bone proteins.},
  author={Enrico Cappellini and Lars Juhl Jensen and Damian Szklarczyk and Aurelien Ginolhac and Rute R da Fonseca and Thomas W Stafford and Steven R. Holen and Matthew J Collins and Ludovic Orlando and Eske Willerslev and Marcus Thomas Pius Gilbert and Jesper V. Olsen},
  journal={Journal of proteome research},
  year={2012},
  volume={11 2},
  pages={
          917-26
        }
}
We used high-sensitivity, high-resolution tandem mass spectrometry to shotgun sequence ancient protein remains extracted from a 43 000 year old woolly mammoth ( Mammuthus primigenius ) bone preserved in the Siberian permafrost. For the first time, 126 unique protein accessions, mostly low-abundance extracellular matrix and plasma proteins, were confidently identified by solid molecular evidence. Among the best characterized was the carrier protein serum albumin, presenting two single amino acid… CONTINUE READING

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