Proteomic analysis of Trypanosoma cruzi secretome: characterization of two populations of extracellular vesicles and soluble proteins.

@article{BayerSantos2013ProteomicAO,
  title={Proteomic analysis of Trypanosoma cruzi secretome: characterization of two populations of extracellular vesicles and soluble proteins.},
  author={Ethel Bayer-Santos and Clemente Aguilar-Bonavides and Silas P Rodrigues and Esteban Maur{\'i}cio Cordero and Alexandre Ferreira Marques and Armando Varela-Ram{\'i}rez and Hyungwon Choi and Nobuko Yoshida and Jos{\'e} Franco da Silveira and Igor C. Almeida},
  journal={Journal of proteome research},
  year={2013},
  volume={12 2},
  pages={883-97}
}
Microorganisms use specialized systems to export virulence factors into host cells. Secretion of effector proteins into the extracellular environment has been described in Trypanosoma cruzi; however, a comprehensive proteomic analysis of the secretome and the secretion mechanisms involved remain elusive. Here, we present evidence that T. cruzi releases proteins associated with vesicles that are formed by at least two different mechanisms. Transmission electron microscopy showed larger vesicles… CONTINUE READING
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