Proteomic analysis of NMDA receptor–adhesion protein signaling complexes

@article{Husi2000ProteomicAO,
  title={Proteomic analysis of NMDA receptor–adhesion protein signaling complexes},
  author={Holger Husi and Malcolm Andrew Ward and Jyoti S Choudhary and Walter P. Blackstock and Seth G. N. Grant},
  journal={Nature Neuroscience},
  year={2000},
  volume={3},
  pages={661-669}
}
N-methyl-D-aspartate receptors (NMDAR) mediate long-lasting changes in synapse strength via downstream signaling pathways. We report proteomic characterization with mass spectrometry and immunoblotting of NMDAR multiprotein complexes (NRC) isolated from mouse brain. The NRC comprised 77 proteins organized into receptor, adaptor, signaling, cytoskeletal and novel proteins, of which 30 are implicated from binding studies and another 19 participate in NMDAR signaling. NMDAR and metabotropic… CONTINUE READING
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