Proteomic analysis of AQP11-null kidney: Proximal tubular type polycystic kidney disease

@inproceedings{Saito2018ProteomicAO,
  title={Proteomic analysis of AQP11-null kidney: Proximal tubular type polycystic kidney disease},
  author={Tatsuya Saito and Yasuko Tanaka and Yoshiyuki Morishita and Kenichi Ishibashi},
  booktitle={Biochemistry and biophysics reports},
  year={2018}
}
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is caused by the mutation of polycystins (PC-1 or PC-2), in which cysts start from the collecting duct to extend to all nephron segments with eventual end stage renal failure. The cyst development is attenuated by a vasopressin V2 receptor antagonist tolvaptan which, however, will not affect proximal tubule cysts devoid of V2 receptor. Aquaporin-11 (AQP11) is expressed selectively in the proximal tubule of the kidney and AQP11-null kidneys… CONTINUE READING
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