Proteomic analysis and brain-specific systems biology in a rodent model of penetrating ballistic-like brain injury.

@article{Boutt2012ProteomicAA,
  title={Proteomic analysis and brain-specific systems biology in a rodent model of penetrating ballistic-like brain injury.},
  author={Angela M. Boutt{\'e} and Changping Yao and Firas H. Kobeissy and Xi-Chun May Lu and Zhiqun Saint Paul Zhang and Kevin K. W. Wang and Kara E. Schmid and Frank C. Tortella and Jitendra R. Dave},
  journal={Electrophoresis},
  year={2012},
  volume={33 24},
  pages={
          3693-704
        }
}
Proteomics and systems biology have significantly contributed to biomarker discovery in the field of brain injury. This study utilized 2D-DIGE-PMF-MS as a preliminary screen to detect biomarkers in a rat model of penetrating ballistic-like brain injury (PBBI). Brain-specific systems biology analysis of brain tissue identified 386 proteins having a fold change of more than 2, of which 321 proteins were increased and 65 were decreased 24 h after PBBI compared to sham controls. The majority of… CONTINUE READING
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