Proteomic Shifts in Embryonic Stem Cells with Gene Dose Modifications Suggest the Presence of Balancer Proteins in Protein Regulatory Networks

@article{Mao2007ProteomicSI,
  title={Proteomic Shifts in Embryonic Stem Cells with Gene Dose Modifications Suggest the Presence of Balancer Proteins in Protein Regulatory Networks},
  author={Lei Mao and Claus Zabel and Marion Herrmann and Tobias Nolden and Florian Mertes and Laetitia Magnol and Caroline Chabert and Daniela Hartl and Yann H{\'e}rault and Jean Maurice Delabar and Thomas Manke and Heinz Himmelbauer and Joachim Klose},
  journal={PLoS ONE},
  year={2007},
  volume={2},
  pages={43628 - 43635}
}
Large numbers of protein expression changes are usually observed in mouse models for neurodegenerative diseases, even when only a single gene was mutated in each case. To study the effect of gene dose alterations on the cellular proteome, we carried out a proteomic investigation on murine embryonic stem cells that either overexpressed individual genes or displayed aneuploidy over a genomic region encompassing 14 genes. The number of variant proteins detected per cell line ranged between 70 and… CONTINUE READING

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