Proteomic Profiling of Bronchoalveolar Lavage Fluid in Critically Ill Patients with Ventilator-Associated Pneumonia

@inproceedings{Nguyen2013ProteomicPO,
  title={Proteomic Profiling of Bronchoalveolar Lavage Fluid in Critically Ill Patients with Ventilator-Associated Pneumonia},
  author={Elizabeth V. Nguyen and Sina Gharib and Steven J. Palazzo and Yu-hua Chow and David R. Goodlett and Lynn M. Schnapp},
  booktitle={PloS one},
  year={2013}
}
RATIONALE Ventilator-associated pneumonia (VAP) is a common complication in patients with acute lung injury (ALI) and can lead to increased morbidity and mortality. Identifying protein profiles specific to VAP in bronchoalveolar lavage fluid (BALF) may aid in earlier diagnosis, elucidate mechanisms of disease, and identify putative targets for therapeutic intervention. METHODS BALF was obtained from 5 normal subjects and 30 ALI patients: 14 with VAP (VAP(+)) and 16 without VAP (VAP(-)). Each… CONTINUE READING