Proteomic Profile of Cryptococcus neoformans Biofilm Reveals Changes in Metabolic Processes

  title={Proteomic Profile of Cryptococcus neoformans Biofilm Reveals Changes in Metabolic
  author={Luc{\'e}lia Santi and Walter O Beys-da-Silva and Markus Berger and Diego Calzolari and J. A. Guimar{\~a}es and James J. Moresco and John R. Yates},
  booktitle={Journal of proteome research},
Cryptococcus neoformans, a pathogenic yeast, causes meningoencephalitis, especially in immunocompromised patients, leading in some cases to death. Microbes in biofilms can cause persistent infections, which are harder to treat. Cryptococcal biofilms are becoming common due to the growing use of brain valves and other medical devices. Using shotgun proteomics we determine the differences in protein abundance between biofilm and planktonic cells. Applying bioinformatic tools, we also evaluated… CONTINUE READING
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