Proteomic Identification of Mitochondrial Targets of Arginase in Human Breast Cancer

@inproceedings{Singh2013ProteomicIO,
  title={Proteomic Identification of Mitochondrial Targets of Arginase in Human Breast Cancer},
  author={Rajan Singh and Nuraly K. Avliyakulov and Melissa Braga and Michael J. Haykinson and Luis Martinez and Vikash Singh and Meher Parveen and Gautam Chaudhuri and Shehla Pervin},
  booktitle={PloS one},
  year={2013}
}
We have previously reported arginase expression in human breast cancer cells and demonstrated that the inhibition of arginase by N(ω) hydroxy L-arginine (NOHA) in MDA-MB-468 cells induces apoptosis. However, arginase expression and its possible molecular targets in human breast tumor samples and potential clinical implications have not been fully elucidated. Here, we demonstrate arginase expression in human breast tumor samples, and several established breast cancer cell lines, in which NOHA… CONTINUE READING