Proteomic Characterization of Inhibitory Synapses Using a Novel pHluorin-tagged γ-Aminobutyric Acid Receptor, Type A (GABAA), α2 Subunit Knock-in Mouse.

@article{Nakamura2016ProteomicCO,
  title={Proteomic Characterization of Inhibitory Synapses Using a Novel pHluorin-tagged γ-Aminobutyric Acid Receptor, Type A (GABAA), α2 Subunit Knock-in Mouse.},
  author={Yasuko Nakamura and Danielle H. Morrow and Amit Modgil and Deborah Huyghe and Tarek Z. Deeb and Michael J. Lumb and Paul A. Davies and Stephen J. Moss},
  journal={The Journal of biological chemistry},
  year={2016},
  volume={291 23},
  pages={12394-407}
}
The accumulation of γ-aminobutyric acid receptors (GABAARs) at the appropriate postsynaptic sites is critical for determining the efficacy of fast inhibitory neurotransmission. Although we know that the majority of synaptic GABAAR subtypes are assembled from α1-3, β, and γ2 subunits, our understanding of how neurons facilitate their targeting to and stabilization at inhibitory synapses is rudimentary. To address these issues, we have created knock-in mice in which the pH-sensitive green… CONTINUE READING
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