Proteomic Analysis of the E3 Ubiquitin-Ligase Hakai Highlights a Role in Plasticity of the Cytoskeleton Dynamics and in the Proteasome System.

@article{DazDaz2017ProteomicAO,
  title={Proteomic Analysis of the E3 Ubiquitin-Ligase Hakai Highlights a Role in Plasticity of the Cytoskeleton Dynamics and in the Proteasome System.},
  author={Andrea D{\'i}az-D{\'i}az and Alba Casas-Pais and Valentina Calamia and Raquel Carballo Castosa and Olaia A Mart{\'i}nez-Iglesias and Daniel Roca-Lema and Isabel Santamarina and Manuel Valladares-Ayerbes and Lourdes Calvo and Venancio Chantada and Ang{\'e}lica Figueroa},
  journal={Journal of proteome research},
  year={2017},
  volume={16 8},
  pages={
          2773-2788
        }
}
Carcinoma, the most common type of cancer, arises from epithelial cells. The transition from adenoma to carcinoma is associated with the loss of E-cadherin and, in consequence, the disruption of cell-cell contacts. E-cadherin is a tumor suppressor, and it is down-regulated during epithelial-to-mesenchymal transition (EMT); indeed, its loss is a predictor of poor prognosis. Hakai is an E3 ubiquitin-ligase protein that mediates E-cadherin ubiquitination, endocytosis and finally degradation… CONTINUE READING
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