Proteome-wide analysis reveals widespread lysine acetylation of major protein complexes in the malaria parasite

@inproceedings{Cobbold2016ProteomewideAR,
  title={Proteome-wide analysis reveals widespread lysine acetylation of major protein complexes in the malaria parasite},
  author={Simon A. Cobbold and Joana Mendonca Santos and Alejandro Ochoa and David Perlman and Manuel Llin{\'a}s},
  booktitle={Scientific reports},
  year={2016}
}
Lysine acetylation is a ubiquitous post-translational modification in many organisms including the malaria parasite Plasmodium falciparum, yet the full extent of acetylation across the parasite proteome remains unresolved. Moreover, the functional significance of acetylation or how specific acetyl-lysine sites are regulated is largely unknown. Here we report a seven-fold expansion of the known parasite 'acetylome', characterizing 2,876 acetylation sites on 1,146 proteins. We observe that lysine… CONTINUE READING
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