Proteome and proteomics: New technologies, new concepts, and new words

@article{Anderson1998ProteomeAP,
  title={Proteome and proteomics: New technologies, new concepts, and new words},
  author={N. Leigh Anderson and Norman G. Anderson},
  journal={ELECTROPHORESIS},
  year={1998},
  volume={19}
}
The goal of proteomics is a comprehensive, quantitative description of protein expression and its changes under the influence of biological perturbations such as disease or drug treatment. Quantitative analysis of protein expression data obtained by high‐throughput methods has led us to define the concept of “regulatory homology” and use it to begin to elucidate the basic structure of gene expression control in vivo. Such investigations lay the groundwork for construction of comprehensive… 
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The concept and technology of proteomics is reviewed with specific reference to applications in medical microbiology, cellular pathology, clinical chemistry, haematology/immunology, pharmacology and toxicology, and state of the art analytical methods with bioinformatics.
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Proteomics research leads to the identification of new protein markers for diagnostic purposes and novel molecular targets for drug identification and understanding.
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The rationale for quantitative proteome analysis is discussed, the limitations in the current standard technology are highlighted, a new experimental approach is introduced, and a new mathematical model is introduced to study steady‐state gene expression and perturbation‐induced changes.
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The current state of proteome research is reviewed in terms of capacity and utility, which indicates that funding bodies are increasingly focused on the usefulness of this capacity.
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