Proteome analysis reveals phosphorylation of ATP synthase beta -subunit in human skeletal muscle and proteins with potential roles in type 2 diabetes.

@article{Hjlund2003ProteomeAR,
  title={Proteome analysis reveals phosphorylation of ATP synthase beta -subunit in human skeletal muscle and proteins with potential roles in type 2 diabetes.},
  author={Kurt H{\o}jlund and Krzysztof Wrzesinski and Peter Mose Larsen and Stephen John Fey and Peter Roepstorff and A Handberg and Flemming Dela and J{\o}rgen Vinten and J. G. Mccormack and Christine Reynet and Henning Beck-Nielsen},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 12},
  pages={
          10436-42
        }
}
Insulin resistance in skeletal muscle is a hallmark feature of type 2 diabetes. An increasing number of enzymes and metabolic pathways have been implicated in the development of insulin resistance. However, the primary cellular cause of insulin resistance remains uncertain. Proteome analysis can quantitate a large number of proteins and their post-translational modifications simultaneously and is a powerful tool to study polygenic diseases like type 2 diabetes. Using this approach on human… CONTINUE READING
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