Proteome analysis of vinca alkaloid response and resistance in acute lymphoblastic leukemia reveals novel cytoskeletal alterations.

@article{Verrills2003ProteomeAO,
  title={Proteome analysis of vinca alkaloid response and resistance in acute lymphoblastic leukemia reveals novel cytoskeletal alterations.},
  author={Nicole M. Verrills and Bradley J Walsh and Gary S. Cobon and Peter G Hains and Maria Kavallaris},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 46},
  pages={45082-93}
}
Vinca alkaloids are used widely in the treatment of both childhood and adult cancers. Their cellular target is the beta-tubulin subunit of alpha/beta-tubulin heterodimers, and they act to inhibit cell division by disrupting microtubule dynamics. Despite the effectiveness of these agents, drug resistance is a major clinical problem. To identify the underlying mechanisms behind vinca alkaloid resistance, we have performed high resolution differential proteome analysis. Treatment of drug-sensitive… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 29 extracted citations

References

Publications referenced by this paper.
Showing 1-2 of 2 references

Proteins Associated with Vinca Alkaloid Resistance

  • L. Rao, D. Perez, E. White
  • J. Cell Biol
  • 1996

Current Protocols in Molecular Biology

  • F. M. Ausubel, R. Brent, +4 authors K. Struhl
  • 1988

Similar Papers

Loading similar papers…