Proteome analysis of the dystrophin-deficient MDX diaphragm reveals a drastic increase in the heat shock protein cvHSP.

@article{Doran2006ProteomeAO,
  title={Proteome analysis of the dystrophin-deficient MDX diaphragm reveals a drastic increase in the heat shock protein cvHSP.},
  author={Philip Doran and Geraldine Ella Savidge Martin and Paul H. Dowling and Harald Jockusch and Kay Ohlendieck},
  journal={Proteomics},
  year={2006},
  volume={6 16},
  pages={
          4610-21
        }
}
Duchenne muscular dystrophy is the most commonly inherited neuromuscular disorder in humans. Although the primary genetic deficiency of dystrophin in X-linked muscular dystrophy is established, it is not well-known how pathophysiological events trigger the actual fibre degeneration. We have therefore performed a DIGE analysis of normal diaphragm muscle versus the severely affected x-linked muscular dystrophy (MDX) diaphragm, which represents an established animal model of dystrophinopathy. Out… CONTINUE READING
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