Proteome analysis of soluble nuclear proteins reveals that HMGB1/2 suppress genotoxic stress in polyglutamine diseases

@article{Qi2007ProteomeAO,
  title={Proteome analysis of soluble nuclear proteins reveals that HMGB1/2 suppress genotoxic stress in polyglutamine diseases},
  author={Mei-ling Qi and Kazuhiko Tagawa and Yasushi Enokido and Natsue Yoshimura and Yo-ichi Wada and Kei Watase and Sho-ichi Ishiura and Ichiro Kanazawa and Juan Botas and Minoru Saitoe and Erich E. Wanker and Hitoshi Okazawa},
  journal={Nature Cell Biology},
  year={2007},
  volume={9},
  pages={402-414}
}
Nuclear dysfunction is a key feature of the pathology of polyglutamine (polyQ) diseases. It has been suggested that mutant polyQ proteins impair functions of nuclear factors by interacting with them directly in the nucleus. However, a systematic analysis of quantitative changes in soluble nuclear proteins in neurons expressing mutant polyQ proteins has not been performed. Here, we perform a proteome analysis of soluble nuclear proteins prepared from neurons expressing huntingtin (Htt) or ataxin… CONTINUE READING