Proteome analysis of cerebrospinal fluid in Guillain-Barré syndrome (GBS).

@article{Lehmensiek2007ProteomeAO,
  title={Proteome analysis of cerebrospinal fluid in Guillain-Barr{\'e} syndrome (GBS).},
  author={Vera Lehmensiek and Sigurd Dietrich S{\"u}\ssmuth and Johannes Brettschneider and Gail Tauscher and Sandra Felk and Frank Gillardon and Hayrettin Tumani},
  journal={Journal of neuroimmunology},
  year={2007},
  volume={185 1-2},
  pages={190-4}
}
We used two-dimensional difference in-gel electrophoresis (2-D-DIGE) for proteome analysis of cerebrospinal fluid (CSF) in Guillain-Barré syndrome (GBS). Spots showing >2-fold difference between GBS and controls were analysed using MALDI-TOF mass spectrometry. Proteins that were up-regulated in GBS included haptoglobin, serine/threonine kinase 10, alpha-1-antitrypsin, SNC73, alpha II spectrin, IgG kappa chain and cathepsin D preprotein, while transferrin, caldesmon, GALT, human heat shock… CONTINUE READING