Proteome analysis demonstrates profound alterations in human dendritic cell nature by TX527, an analogue of vitamin D.

@article{Ferreira2009ProteomeAD,
  title={Proteome analysis demonstrates profound alterations in human dendritic cell nature by TX527, an analogue of vitamin D.},
  author={Gabriela Bomfim Ferreira and Evelyne van Etten and Kasper Lage and Daniel A. Hansen and Yves Moreau and Christopher T. Workman and Mark Waer and Annemieke Verstuyf and Etienne Waelkens and Lut Overbergh and Chantal Mathieu},
  journal={Proteomics},
  year={2009},
  volume={9 14},
  pages={3752-64}
}
Structural analogues of vitamin D have been put forward as therapeutic agents able to exploit the immunomodulatory effects of vitamin D, without its undesired calcemic side effects. We have demonstrated that TX527 affects dendritic cell (DC) maturation in vitro, resulting in the generation of a tolerogenic cell. In the present study, we aimed to explore the global protein changes induced by the analogue in immature DC (iDC) and mature human DC and to correlate them with alterations in DC… CONTINUE READING
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