Proteome analysis and functional expression identify mortalin as an antiapoptotic gene induced by elevation of [Na+]i/[K+]i ratio in cultured vascular smooth muscle cells.

@article{Taurin2002ProteomeAA,
  title={Proteome analysis and functional expression identify mortalin as an antiapoptotic gene induced by elevation of [Na+]i/[K+]i ratio in cultured vascular smooth muscle cells.},
  author={Sebastien Taurin and Volkan Seyrantepe and Sergei N. Orlov and T L Tremblay and Pierre Thibault and Martin R. Bennett and Pavel Hamet and Alexey V Pshezhetsky},
  journal={Circulation research},
  year={2002},
  volume={91 10},
  pages={915-22}
}
Apoptosis of vascular smooth muscle cells (VSMCs) plays an important role in remodeling of vessel walls, one of the major determinants of long-term blood pressure elevation and an independent risk factor for cardiovascular morbidity and mortality. Recently, we have found that apoptosis in cultured VSMCs can be inhibited by inversion of the intracellular [Na+]/[K+] ratio after the sustained blockage of the Na+,K+-ATPase by ouabain. To understand the mechanism of ouabain action, we analyzed… CONTINUE READING

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