Proteome adaptation of Saccharomyces cerevisiae to severe calorie restriction in Retentostat cultures.


Stationary-phase, carbon-starved shake-flask cultures of Saccharomyces cerevisiae are popular models for studying eukaryotic chronological aging. However, their nutrient-starved physiological status differs substantially from that of postmitotic metazoan cells. Retentostat cultures offer an attractive alternative model system in which yeast cells… (More)
DOI: 10.1021/pr5003388

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